Rush-it Ron is upcoming spin-off of the 2012 animated film Wreck-it Ralph.
- Chris Sanders as Rush-it Ron, the hero of Rush-it Ron. He is inspired by classic video game heroes such as Sonic the Hedgehog, but he resembles Shoutmon.
- Tara King as Leila Bunny, a beautiful, white rabbit who is a racer and glitch in Cute Kart.
- Bill Hader as Harold, the hero of Rush-it Ron. He is inspired by Rotor the Walrus but he is a human. He is a fat, charismatic, good-hearted, friendly boy.
- Bruce Campbell as King Grizzly/Motor, the ruler of Cute Kart. He is inspired by Bear King. As King Grizzly, he is large obese man with black hair and whiskers, who is dressed in clothes that match his card and animal themes, which includes a furred captain's jacket with the collar shaped like a spade, a blue shirt underneath it with the top part unbuttoned. The king's most notable feature, would be his large, golden crown that is usually slanted atop his head. As Motor, he was still large in nature, but had greyish/purple skin, a bald head, a reptilian crocodile-like face, and beaming greenish/yellow eyes and sharp teeth.
- Bowser, Donkey Kong, Yoshi, Mario, Wario, and a Super Mushroom from Super Mario Bros.
- Tails, Amy, Vector, Dr. Eggman, Snively, and Sonic the Hedgehog from Sonic the Hedgehog
- Q*bert, Coily, Slick, Sam, and Ugg from Q*bert
- Neff from Altered Beast
- Knight and Ostrich from Joust
- Kano and Smoke from Mortal Kombat
- A Bartender from Tapper
- Pac-Man, Clyde Ghost Monster (Kevin Deters), Inky Ghost Monster, Blinky Ghost Monster, and Pinky Ghost Monster from Pac-Man
- Chun-Li,, Ken (Reuben Langdon), Zangief (Rich Moore), M. Bison (Gerald C. Rivers), Cammy, and Blanka from Street Fighter
- John C. Reilly as Mario from Super Mario Bros.
- Maurice LaMarche as Root Beer Tapper, the bartender from Tapper.
- Roger Craig Smith as Sonic from Sonic the Hedgehog.
- Bill Hader as Basko, a green, bird-like hero who attends the Good-Anon support group.
- Martin Short as Billy, a penguin-like hero who attends the Good-Anon support group.
- Carlos Alazraqui as Vector the Crocodile who attends the Good-Anon support group.